His group also study anti-inflammatory mechanisms in the gut, including cellular mediators of immunosuppression, such as regulatory T-cells and mesenchymal stromal cells. Recent work has focused on understand how cell-specific and tissue-specific transcriptional modules unmask new insights in to the pathogenesis of gut inflammation, and how these signatures could be harnessed to predict IBD patient outcomes, including their response specific therapies. These tools will hopefully change management algorithms for IBD patients to guide personalized, precision medicine approaches. 

Nick Powell

Professor and Consultant in Gastroenterology
Faculty of Medicine, Imperial College London

Honorary Consultant in Gastroenterology
Royal Marsden Hospital

Nick qualified from Birmingham University Medical school with various honours and prizes, including honours in Medicine, honours and distinction in Pathology. He completed clinical training in gastroenterology and internal medicine in London (Hammersmith, St Mary’s). He has also been awarded an MSc (Imperial College London) and PhD in immunology (King’s College London). Major funding has been awarded by the Wellcome Trust, MRC and Crohn’s and Colitis UK. Some key publications include; Powell N, et al. Gastroenterology (2015); 149:456-467, Goldberg R, et al. Nature Reviews in Gastroenterology and Hepatology (2015); 12:271-283, Powell N, et al. Immunity (2012); 37:674-84.   

Research interests: His research group focuses on the molecular and cellular mechanisms responsible for mediating chronic intestinal inflammation, including mechanisms of cytokine-mediated tissue injury and mode of pathogenicity of key mucosal dwelling cells, including innate lymphoid cells and T-cells. The major disease areas of interest are inflammatory bowel disease (comprising Crohn's disease and ulcerative colitis, and more recently the mechanisms of intestinal injury caused when cancer patients are treated with immune checkpoint inhibitors.